TheCables1Gene in Glucocorticoid Regulation of Pituitary Corticotrope Growth and Cushing Disease | Zendy

Audrey Roussel-Gervais | Zendy; Catherine Couture | Zendy; David Langlais | Zendy; Shinobu Takayasu | Zendy; Aurélio Balsalobre | Zendy; Bo R. Rueda | Zendy; Lawrence Zukerberg | Zendy; Dominique FigarellaBranger | Zendy; Thierry Brue | Zendy; Jacques Drouin | Zendy

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TheCables1Gene in Glucocorticoid Regulation of Pituitary Corticotrope Growth and Cushing Disease

Author(s) -

Audrey Roussel-Gervais,

Catherine Couture,

David Langlais,

Shinobu Takayasu,

Aurélio Balsalobre,

Bo R. Rueda,

Lawrence Zukerberg,

Dominique FigarellaBranger,

Thierry Brue,

Jacques Drouin

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-3324

Subject(s) - corticotropic cell , cushing's disease , glucocorticoid , endocrinology , medicine , somatotropic cell , growth hormone , pituitary gland , biology , disease , hormone

Cushing disease (CD) is due to pituitary corticotrope adenomas that produce unrestrained ACTH secretion and have lost the negative feedback exerted by glucocorticoids (GCs). GCs also restrain corticotrope proliferation, and the mechanisms of this inhibition are poorly understood.

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