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Cushing disease (CD) is due to pituitary corticotrope adenomas that produce unrestrained ACTH secretion and have lost the negative feedback exerted by glucocorticoids (GCs). GCs also restrain corticotrope proliferation, and the mechanisms of this inhibition are poorly understood.

TheCables1Gene in Glucocorticoid Regulation of Pituitary Corticotrope Growth and Cushing Disease