Coming Up Short: Risks of Bias in Assessing Psychological Outcomes in Growth Hormone Therapy for Short Stature | Zendy

Melissa Gardner | Zendy; Michael Boshart | Zendy; Carlos E. Yegüez | Zendy; Kaushik Desai | Zendy; David E. Sandberg | Zendy

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Coming Up Short: Risks of Bias in Assessing Psychological Outcomes in Growth Hormone Therapy for Short Stature

Author(s) -

Melissa Gardner,

Michael Boshart,

Carlos E. Yegüez,

Kaushik Desai,

David E. Sandberg

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-3256

Subject(s) - psychosocial , meta analysis , blinding , medicine , short stature , publication bias , clinical psychology , growth hormone , idiopathic short stature , relative risk , systematic review , randomized controlled trial , medline , confidence interval , psychiatry , hormone , political science , law

Two often cited assumptions for treating children with GH are that short stature (SS), as an isolated physical characteristic, is associated with psychosocial morbidity and that GH treatment may increase height and improve psychological adjustment. Findings across studies regarding the psychological consequences associated with GH management of children with SS are variable and frequently contradictory. The purpose of this systematic review is to evaluate the degree to which any conclusions about the relative risks or benefits of GH treatment on psychological outcomes can be made based on the published literature.

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