β-Cell Glucose Sensitivity Is Linked to Insulin/Glucagon Bihormonal Cells in Nondiabetic Humans | Zendy

Teresa Mezza | Zendy; Gian Pio Sorice | Zendy; Caterina Conte | Zendy; Vinsin A. Sun | Zendy; C. Cefalo | Zendy; Simona Moffa | Zendy; Alfredo Pontecorvi | Zendy; Andrea Mari | Zendy; Rohit Kulkarni | Zendy; Andrea Giaccari | Zendy

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β-Cell Glucose Sensitivity Is Linked to Insulin/Glucagon Bihormonal Cells in Nondiabetic Humans

Author(s) -

Teresa Mezza,

Gian Pio Sorice,

Caterina Conte,

Vinsin A. Sun,

C. Cefalo,

Simona Moffa,

Alfredo Pontecorvi,

Andrea Mari,

Rohit Kulkarni,

Andrea Giaccari

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-2802

Subject(s) - medicine , endocrinology , islet , neogenesis , transdifferentiation , insulin , glucagon , insulin oscillation , insulin resistance , pancreas , biology , diabetes mellitus , alpha cell , pancreatic hormone , cell , beta cell , biochemistry

Insulin resistance impacts virtually all tissues, including pancreatic β cells. Individuals with insulin resistance, but without diabetes, exhibit an increased islet size because of an elevated number of both β and α cells. Neogenesis from duct cells and transdifferentiation of α cells have been postulated to contribute to the β-cell compensatory response to insulin resistance.

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