A Report of Three Cases With Acquired Generalized Lipodystrophy With Distinct Autoimmune Conditions Treated With Metreleptin | Zendy

Jasmin Lebastchi | Zendy; Nevin Ajluni | Zendy; Adam Neidert | Zendy; Elif A Oral | Zendy

Open Access

A Report of Three Cases With Acquired Generalized Lipodystrophy With Distinct Autoimmune Conditions Treated With Metreleptin

Author(s) -

Jasmin Lebastchi,

Nevin Ajluni,

Adam Neidert,

Elif A Oral

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-2589

Subject(s) - medicine , autoimmune hepatitis , lipodystrophy , hypertriglyceridemia , hepatosplenomegaly , insulin resistance , endocrinology , fatty liver , autoimmune disease , hepatitis , immunology , disease , insulin , triglyceride , human immunodeficiency virus (hiv) , cholesterol , antiretroviral therapy , viral load

Acquired generalized lipodystrophy (AGL) is associated with leptin deficiency as a result of adipose tissue loss and hypertriglyceridemia, insulin resistance, and hepatic steatosis. It may coexist with other autoimmune diseases such as Hashimoto's thyroiditis, rheumatoid arthritis, hemolytic anemia, and chronic active hepatitis. Metreleptin therapy has been shown to improve metabolic abnormalities in lipodystrophy, but the effect on AGL patients with active autoimmune disease is unknown.

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