Early Increases in Bile Acids Post Roux-en-Y Gastric Bypass Are Driven by Insulin-Sensitizing, Secondary Bile Acids | Zendy

Vance L. Albaugh | Zendy; Charles R. Flynn | Zendy; Steven Cai | Zendy; Yi Xiao | Zendy; Robyn A. Tamboli | Zendy; Naji N. Abumrad | Zendy

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Early Increases in Bile Acids Post Roux-en-Y Gastric Bypass Are Driven by Insulin-Sensitizing, Secondary Bile Acids

Author(s) -

Vance L. Albaugh,

Charles R. Flynn,

Steven Cai,

Yi Xiao,

Robyn A. Tamboli,

Naji N. Abumrad

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-2467

Subject(s) - bile acid , ursodeoxycholic acid , deoxycholic acid , medicine , weight loss , taurine , endocrinology , glycine , insulin , hormone , amino acid , obesity , gastroenterology , chemistry , biochemistry

Roux-en-Y gastric bypass (RYGB) is the most effective treatment for morbid obesity and resolution of diabetes. Over the last decade, it has become well accepted that this resolution of diabetes occurs before significant weight loss; however, the mechanisms behind this effect remain unknown and could represent novel therapeutic targets for obesity and diabetes. Bile acids have been identified as putative mediators of these weight loss-independent effects.

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