Prothymosin-α Overexpression Contributes to the Development of Insulin Resistance | Zendy

Yu-Chu Su | Zendy; Horng-Yih Ou | Zendy; HungTsung Wu | Zendy; Pensée Wu | Zendy; Yi-Cheng Chen | Zendy; Bing-Hua Su | Zendy; AiLi Shiau | Zendy; ChihJen Chang | Zendy; ChaoLiang Wu | Zendy

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Prothymosin-α Overexpression Contributes to the Development of Insulin Resistance

Author(s) -

Yu-Chu Su,

Horng-Yih Ou,

HungTsung Wu,

Pensée Wu,

Yi-Cheng Chen,

Bing-Hua Su,

AiLi Shiau,

ChihJen Chang,

ChaoLiang Wu

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-2277

Subject(s) - insulin resistance , medicine , endocrinology , inflammation , insulin , oxidative stress , glut4 , diabetes mellitus , biology , insulin receptor

Prothymosin-α (ProT) is involved in oxidative stress, inflammation, cell proliferation, and apoptosis. Increased oxidative stress and chronic inflammation participate in the pathogenesis of diabetes. A recent study found that ProT is a ligand of toll-like receptor 4, which plays an important role in the development of insulin resistance. However, its physiological role remains poorly understood.

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