Estradiol Priming Improves Gonadotrope Sensitivity and Pro-Inflammatory Cytokines in Obese Women | Zendy

Zain Al-Safi | Zendy; Huayu Liu | Zendy; Nichole E. Carlson | Zendy; Justin Chosich | Zendy; Jennifer Lesh | Zendy; C. Robledo | Zendy; Andrew P. Bradford | Zendy; Nancy A. Gee | Zendy; Tzu Phang | Zendy; Nanette Santoro | Zendy; Wendy M. Kohrt | Zendy; Alex J. Polotsky | Zendy

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Estradiol Priming Improves Gonadotrope Sensitivity and Pro-Inflammatory Cytokines in Obese Women

Author(s) -

Zain Al-Safi,

Huayu Liu,

Nichole E. Carlson,

Justin Chosich,

Jennifer Lesh,

C. Robledo,

Andrew P. Bradford,

Nancy A. Gee,

Tzu Phang,

Nanette Santoro,

Wendy M. Kohrt,

Alex J. Polotsky

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-1946

Subject(s) - medicine , endocrinology , estrogen , hypogonadotropic hypogonadism , luteal phase , gonadotropin , follicular phase , hormone

Obesity is associated with a pro-inflammatory state and relative hypogonadotropic hypogonadism. Estrogen (E2) is a potential link between these phenomena because it exhibits negative feedback on gonadotropin secretion and also inhibits production of pro-inflammatory cytokines.

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