Effect of Early Parenteral Nutrition on the HPA Axis and on Treatment With Corticosteroids in Intensive Care Patients
Author(s) -
Philippe Meersseman,
Eva Boonen,
Bram Peeters,
Sarah Vander Perre,
Pieter Wouters,
Lies Langouche,
Greet Van den Berghe
Publication year - 2015
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2015-1846
Subject(s) - medicine , septic shock , odds ratio , adrenal insufficiency , confidence interval , shock (circulatory) , hydrocortisone , incidence (geometry) , endocrinology , parenteral nutrition , gastroenterology , randomized controlled trial , sepsis , physics , optics
Nutrition can affect the hypothalamus-pituitary-adrenal axis. We hypothesized that early administration of parenteral nutrition (PN) during critical illness reduces plasma ACTH and cortisol concentrations and thereby increases the use of corticosteroids.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom