Additive Genetic Effects on Circulating Periostin Contribute to the Heritability of Bone Microstructure | Zendy

Nicolas Bonnet | Zendy; Emmanuel Biver | Zendy; Claire Durosier | Zendy; Thierry Chevalley | Zendy; René Rizzoli | Zendy; Serge Ferrari | Zendy

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Additive Genetic Effects on Circulating Periostin Contribute to the Heritability of Bone Microstructure

Author(s) -

Nicolas Bonnet,

Emmanuel Biver,

Claire Durosier,

Thierry Chevalley,

René Rizzoli,

Serge Ferrari

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-1183

Subject(s) - periostin , heritability , microstructure , genetics , biology , materials science , composite material , extracellular matrix

Genetic factors account for 60-80% of the areal bone mineral density (aBMD) variance, whereas the heritability of bone microstructure is not clearly established. aBMD and microstructure are under the control of osteocytes, which regulate bone formation through the expression of molecules such as sclerostin (SOST) and periostin (POSTN).

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