Age-Related Lipid Metabolic Signature in HumanLMNA-Lipodystrophic Stem Cell-Derived Adipocytes | Zendy

Patricia Sánchez | Zendy; Arantza Infante | Zendy; Garbiñe Ruiz de Eguino | Zendy; Jorge Fuentes-Maestre | Zendy; José Manuel GarcíaVerdugo | Zendy; Clara I. Rodrı́guez | Zendy

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Age-Related Lipid Metabolic Signature in HumanLMNA-Lipodystrophic Stem Cell-Derived Adipocytes

Author(s) -

Patricia Sánchez,

Arantza Infante,

Garbiñe Ruiz de Eguino,

Jorge Fuentes-Maestre,

José Manuel GarcíaVerdugo,

Clara I. Rodrı́guez

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-4528

Subject(s) - lipid droplet , lmna , endoplasmic reticulum , lamin , lipid metabolism , unfolded protein response , chemistry , adipose tissue , lipogenesis , mesenchymal stem cell , lipotoxicity , microbiology and biotechnology , biology , medicine , endocrinology , biochemistry , insulin resistance , insulin , nucleus

Lamin A (LMNA)-linked lipodystrophies belong to a group of clinical disorders characterized by a redistribution of adipose tissue with a variable range of metabolic complications. The leading cause of these disorders is the nonphysiological accumulation of the lamin A precursor, prelamin A. However, the molecular mechanisms by which prelamin A induces the pathology remain unclear.

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