Circulating MKRN3 Levels Decline Prior to Pubertal Onset and Through Puberty: A Longitudinal Study of Healthy Girls | Zendy

Casper P. Hagen | Zendy; Kaspar Sørensen | Zendy; Mikkel G. Mieritz | Zendy; Trine Holm Johannsen | Zendy; Kristian Almstrup | Zendy; Anders Juul | Zendy

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Circulating MKRN3 Levels Decline Prior to Pubertal Onset and Through Puberty: A Longitudinal Study of Healthy Girls

Author(s) -

Casper P. Hagen,

Kaspar Sørensen,

Mikkel G. Mieritz,

Trine Holm Johannsen,

Kristian Almstrup,

Anders Juul

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-4462

Subject(s) - endocrinology , medicine , menarche , precocious puberty , breast development , confidence interval , population , hormone , environmental health

Puberty is initiated by a complex interaction of suppressing and stimulating factors. Genetic studies of familial central precocious puberty have suggested makorin ring finger protein 3 (MKRN3) as a major inhibitor of GnRH secretion during childhood. Furthermore, genetic variation near MKRN3 (rs12148769) affects age at menarche in healthy girls.

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