Open AccessPrimary Aldosteronism andARMC5Variants
Author(s) -
Mihail Zilbermint,
Paraskevi Xekouki,
Fábio R. Faucz,
Annabel Berthon,
Alexandra Gkourogianni,
Marie Helene Schernthaner-Reiter,
Maria Batsis,
Ninet Sinaii,
Martha Quezado,
Maria J. Merino,
Aaron Hodes,
Smita Baid Abraham,
Rossella Libé,
Guillaume Assié,
Stéphanie Espiard,
Ludivine Drougat,
Bruno Ragazzon,
Adam R. Davis,
Samson Y. Gebreab,
Ryan Neff,
Electron Kebebew,
Jérôme Bertherat,
Maya Lodish,
Constantine A. Stratakis
Publication year - 2015
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2014-4167
Subject(s) - primary aldosteronism , medicine , endocrinology , aldosterone
Primary aldosteronism is one of the leading causes of secondary hypertension, causing significant morbidity and mortality. A number of genetic defects have recently been identified in primary aldosteronism, whereas we identified mutations in ARMC5, a tumor-suppressor gene, in cortisol-producing primary macronodular adrenal hyperplasia.
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