Mast Cell Hyperplasia Is Associated With Aldosterone Hypersecretion in a Subset of Aldosterone-Producing Adenomas | Zendy

Céline Duparc | Zendy; L Moreau | Zendy; José Felipe Golib Dzib | Zendy; Hadrien-Gaël Boyer | Zendy; Milène Tetsi Nomigni | Zendy; Isabelle Boutelet | Zendy; Sheerazed Boulkroun | Zendy; Kuniaki Mukai | Zendy; Arndt Benecke | Zendy; Laurence Amar | Zendy; Françoise Gobet | Zendy; Tchao Méatchi | Zendy; PierreFrançois Plouin | Zendy; MariaChristina Zennaro | Zendy; Estelle Louiset | Zendy; Hervé Lefèbvre | Zendy

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Mast Cell Hyperplasia Is Associated With Aldosterone Hypersecretion in a Subset of Aldosterone-Producing Adenomas

Author(s) -

Céline Duparc,

L Moreau,

José Felipe Golib Dzib,

Hadrien-Gaël Boyer,

Milène Tetsi Nomigni,

Isabelle Boutelet,

Sheerazed Boulkroun,

Kuniaki Mukai,

Arndt Benecke,

Laurence Amar,

Françoise Gobet,

Tchao Méatchi,

PierreFrançois Plouin,

MariaChristina Zennaro,

Estelle Louiset,

Hervé Lefèbvre

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-3660

Subject(s) - aldosterone , hyperplasia , mast cell , hyperaldosteronism , endocrinology , adenoma , medicine , immunology

Adrenal mast cells can stimulate aldosterone secretion through the local release of serotonin (5-HT) and activation of the 5-HT4 receptor (5-HT4). In aldosterone-producing adenomas (APAs), 5-HT4 receptor is overexpressed and the administration of 5-HT4 receptor agonists to patients with APA increases plasma aldosterone levels. These data and the well-documented role of mast cells in tumorigenesis suggest that mast cells may be involved in the pathophysiology of APA.

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