Liver Fat Content and Hepatic Insulin Sensitivity in Overweight Patients With Type 1 Diabetes
Author(s) -
Gemma Llauradó,
Ksenia Sevastianova,
Sanja Sädevirta,
Antti Hakkarainen,
Nina Lundbom,
Marju OrhoMelander,
PerHenrik Groop,
Carol Forsblom,
Hannele YkiJärvinen
Publication year - 2014
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2014-3050
Subject(s) - medicine , endocrinology , hyperinsulinemia , insulin , overweight , lipogenesis , type 1 diabetes , lipolysis , diabetes mellitus , fatty liver , type 2 diabetes , insulin resistance , nonalcoholic fatty liver disease , obesity , adipose tissue , disease
Patients with type 1 diabetes mellitus (T1DM) lack the portal/peripheral insulin gradient, which might diminish insulin stimulation of hepatic lipogenesis and protect against development of nonalcoholic fatty liver disease (NAFLD). We compared liver fat content and insulin sensitivity of hepatic glucose production and lipolysis between overweight T1DM patients and nondiabetic subjects.
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