Nitric Oxide and cGMP Induce COX-2 Expression and PGE2Production in Human Granulosa Cells Through CREB Signaling Pathway | Zendy

Lanlan Fang | Zendy; HsunMing Chang | Zendy; JungChien Cheng | Zendy; Peter C. K. Leung | Zendy; Yingpu Sun | Zendy

Open Access

Nitric Oxide and cGMP Induce COX-2 Expression and PGE₂Production in Human Granulosa Cells Through CREB Signaling Pathway

Author(s) -

Lanlan Fang,

HsunMing Chang,

JungChien Cheng,

Peter C. K. Leung,

Yingpu Sun

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-2886

Subject(s) - creb , prostaglandin e2 , nitric oxide , chemistry , gene knockdown , microbiology and biotechnology , cyclic amp response element binding protein , endocrinology , prostaglandin e , medicine , signal transduction , biology , apoptosis , biochemistry , transcription factor , gene

It is well known that cyclooxygenase-2 (COX-2) and its major derivative product prostaglandin E2 (PGE2) play key regulatory roles in the ovulation process. Animal studies have demonstrated that the inhibition of nitric oxide (NO) suppresses ovarian PGE2 production and ovulation. Although the expression of NO synthases has been detected in human granulosa cells, the effect of NO on COX-2 expression and PGE2 production in these cells remains unknown.

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