Overweight/Obese Adults With Pituitary Disorders Require Lower Peak Growth Hormone Cutoff Values on Glucagon Stimulation Testing to Avoid Overdiagnosis of Growth Hormone Deficiency | Zendy

Laura E. Dichtel | Zendy; Kevin C.J. Yuen | Zendy; Miriam A. Bredella | Zendy; Anu V. Gerweck | Zendy; Brian M. Russell | Zendy; Ariana D. Riccio | Zendy; Michelle H. Gurel | Zendy; Patrick M. Sluss | Zendy; Beverly M. K. Biller | Zendy; Karen K. Miller | Zendy

Open Access

Overweight/Obese Adults With Pituitary Disorders Require Lower Peak Growth Hormone Cutoff Values on Glucagon Stimulation Testing to Avoid Overdiagnosis of Growth Hormone Deficiency

Author(s) -

Laura E. Dichtel,

Kevin C.J. Yuen,

Miriam A. Bredella,

Anu V. Gerweck,

Brian M. Russell,

Ariana D. Riccio,

Michelle H. Gurel,

Patrick M. Sluss,

Beverly M. K. Biller,

Karen K. Miller

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-2830

Subject(s) - overdiagnosis , medicine , growth hormone deficiency , overweight , endocrinology , body mass index , insulin tolerance test , cutoff , obesity , hypopituitarism , hormone , growth hormone , insulin resistance , insulin sensitivity , physics , quantum mechanics

Obesity is associated with diminished GH secretion, which may result in the overdiagnosis of adult GH deficiency (GHD) in overweight/obese pituitary patients. However, there are no body mass index (BMI)-specific peak GH cutoffs for the glucagon stimulation test (GST), the favored dynamic test for assessing adult GHD in the United States.

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