Obesity-Induced Down-Regulation of the Mitochondrial Translocator Protein (TSPO) Impairs Placental Steroid Production | Zendy

Luciana Lassance | Zendy; Maricela Haghiac | Zendy; Judi Minium | Zendy; Patrick M. Catalano | Zendy; Sylvie Hauguel de Mouzon | Zendy

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Obesity-Induced Down-Regulation of the Mitochondrial Translocator Protein (TSPO) Impairs Placental Steroid Production

Author(s) -

Luciana Lassance,

Maricela Haghiac,

Judi Minium,

Patrick M. Catalano,

Sylvie Hauguel de Mouzon

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-2792

Subject(s) - translocator protein , mitochondrion , steroid , chemistry , microbiology and biotechnology , medicine , endocrinology , biology , biochemistry , inflammation , hormone , neuroinflammation

Low concentrations of estradiol and progesterone are hallmarks of adverse pregnancy outcomes as is maternal obesity. During pregnancy, placental cholesterol is the sole source of sex steroids. Cholesterol trafficking is the limiting step in sex steroid biosynthesis and is mainly mediated by the translocator protein (TSPO), present in the mitochondrial outer membrane.

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