The Hepatic Expression of Vitamin D Receptor Is Inversely Associated With the Severity of Liver Damage in Genotype 1 Chronic Hepatitis C Patients | Zendy

Salvatore Petta | Zendy; Stefania Grimaudo | Zendy; Claudio Tripodo | Zendy; Daniela Cabibi | Zendy; Marco Calvaruso | Zendy; Antonietta Di Cristina | Zendy; Carla Guarnotta | Zendy; Fabio Salvatore Macaluso | Zendy; Maria Giovanna Minissale | Zendy; Giulio Marchesini | Zendy; Antonio Craxı̀ | Zendy

Open Access

The Hepatic Expression of Vitamin D Receptor Is Inversely Associated With the Severity of Liver Damage in Genotype 1 Chronic Hepatitis C Patients

Author(s) -

Salvatore Petta,

Stefania Grimaudo,

Claudio Tripodo,

Daniela Cabibi,

Marco Calvaruso,

Antonietta Di Cristina,

Carla Guarnotta,

Fabio Salvatore Macaluso,

Maria Giovanna Minissale,

Giulio Marchesini,

Antonio Craxı̀

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-2741

Subject(s) - calcitriol receptor , medicine , autoimmune hepatitis , vitamin d and neurology , liver biopsy , endocrinology , fibrosis , liver disease , vitamin d binding protein , western blot , hepatic fibrosis , hepatitis , gastroenterology , biopsy , biology , biochemistry , gene

Low 25-hydroxyvitamin D serum levels have been associated with the severity of liver fibrosis in genotype 1 chronic hepatitis C patients (G1CHC), and experimental evidence suggested a hepatoprotective role of vitamin D via interaction with hepatic vitamin D receptor (VDR). We assessed the hepatic expression of VDR protein and its association with liver disease severity.

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