The Polycystic Ovary Syndrome Evolutionary Paradox: a Genome-Wide Association Studies–Based, in silico, Evolutionary Explanation | Zendy

Livio Casarini | Zendy; Giulia Brigante | Zendy

Open Access

The Polycystic Ovary Syndrome Evolutionary Paradox: a Genome-Wide Association Studies–Based, in silico, Evolutionary Explanation

Author(s) -

Livio Casarini,

Giulia Brigante

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-2703

Subject(s) - biology , international hapmap project , polycystic ovary , genetics , single nucleotide polymorphism , genetic association , genome wide association study , genetic heterogeneity , genetic distance , allele frequency , evolutionary biology , allele , genetic variation , genotype , phenotype , gene , obesity , endocrinology , insulin resistance

Polycystic ovary syndrome (PCOS) is a common female endocrine disorder characterized by phenotypes ranging from hyperandrogenism to metabolic disorders, more prevalent in people of African/Caucasian and Asian ancestry. Because PCOS impairs fertility without diminishing in prevalence, it was considered an evolutionary paradox. Genome-Wide Association Studies identified 17 single nucleotide polymorphisms (SNPs) associated with PCOS, with different allele frequencies, ethnicity-related, in 11 susceptibility loci.

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