Further Investigation in Europeans of Susceptibility Variants for Polycystic Ovary Syndrome Discovered in Genome-Wide Association Studies of Chinese Individuals | Zendy

Meredith Brower | Zendy; Michelle R. Jones | Zendy; Jerome I. Rotter | Zendy; Ronald M. Krauss | Zendy; Richard S. Legro | Zendy; Ricardo Azziz | Zendy; Mark O. Goodarzi | Zendy

Open Access

Further Investigation in Europeans of Susceptibility Variants for Polycystic Ovary Syndrome Discovered in Genome-Wide Association Studies of Chinese Individuals

Author(s) -

Meredith Brower,

Michelle R. Jones,

Jerome I. Rotter,

Ronald M. Krauss,

Richard S. Legro,

Ricardo Azziz,

Mark O. Goodarzi

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-2689

Subject(s) - genome wide association study , polycystic ovary , genotyping , single nucleotide polymorphism , genetic association , genetics , biology , allele , medicine , genotype , insulin resistance , gene , obesity

Two genome-wide association studies (GWAS) of polycystic ovary syndrome (PCOS) have identified 11 susceptibility loci in Chinese individuals. Some of the risk loci identified in Chinese cohorts, mostly from the first GWAS, have been replicated in Europeans. Replication of the loci from the second GWAS in European cohorts is necessary to determine whether the same variants confer risk for PCOS in multiple ethnicities.

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