Determinants of Altered Sleep-Wake Rhythmicity in Patients Treated for Nonfunctioning Pituitary Macroadenomas | Zendy

Sjoerd D. Joustra | Zendy; E. Kruijssen | Zendy; Marco J. T. Verstegen | Zendy; Alberto M. Pereira | Zendy; Nienke R. Biermasz | Zendy

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Determinants of Altered Sleep-Wake Rhythmicity in Patients Treated for Nonfunctioning Pituitary Macroadenomas

Author(s) -

Sjoerd D. Joustra,

E. Kruijssen,

Marco J. T. Verstegen,

Alberto M. Pereira,

Nienke R. Biermasz

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-2602

Subject(s) - actigraphy , medicine , circadian rhythm , hypopituitarism , excessive daytime sleepiness , hydrocortisone , sleep onset , endocrinology , cohort , sleep disorder , insomnia , psychiatry

In a cohort of 17 patients treated for nonfunctioning pituitary macroadenoma (NFMA), we observed alterations in polysomnographic sleep characteristics and actigraphic sleep-wake rhythmicity, and subjective fatigue, daytime somnolence, and low sleep quality. We aimed to confirm the actigraphic data in a larger scale cohort of NFMA patients, powered to address risk factors for altered rhythmicity, including the effects of hydrocortisone replacement.

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