Impact of Duration of Critical Illness on the Adrenal Glands of Human Intensive Care Patients | Zendy

Eva Boonen | Zendy; Lies Langouche | Zendy; Thomas Janssens | Zendy; Philippe Meersseman | Zendy; Hilke Vervenne | Zendy; Emilie De Samblanx | Zendy; Zoë Pironet | Zendy; Lisa Van Dijck | Zendy; Sarah Vander Perre | Zendy; Inge Derese | Zendy; Greet Van den Berghe | Zendy

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Impact of Duration of Critical Illness on the Adrenal Glands of Human Intensive Care Patients

Author(s) -

Eva Boonen,

Lies Langouche,

Thomas Janssens,

Philippe Meersseman,

Hilke Vervenne,

Emilie De Samblanx,

Zoë Pironet,

Lisa Van Dijck,

Sarah Vander Perre,

Inge Derese,

Greet Van den Berghe

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-2429

Subject(s) - medicine , endocrinology , adrenal insufficiency , intensive care unit , adrenal cortex , glucocorticoid receptor , intensive care , adrenocorticotropic hormone , stimulation , h&e stain , steroidogenic acute regulatory protein , glucocorticoid , hormone , immunohistochemistry , biology , gene expression , intensive care medicine , biochemistry , gene

Adrenal insufficiency is considered to be prevalent during critical illness, although the pathophysiology, diagnostic criteria, and optimal therapeutic strategy remain controversial. During critical illness, reduced cortisol breakdown contributes substantially to elevated plasma cortisol and low plasma ACTH concentrations.

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