Genetic Predisposition to Papillary Thyroid Carcinoma: Involvement of FOXE1, TSHR, and a Novel lincRNA Gene, PTCSC2 | Zendy

Huiling He | Zendy; Wei Li | Zendy; Sandya Liyanarachchi | Zendy; Jarosław Jendrzejewski | Zendy; Mukund Srinivas | Zendy; Ramana V. Davuluri | Zendy; Rebecca Nagy | Zendy; Albert de la Chapelle | Zendy

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Genetic Predisposition to Papillary Thyroid Carcinoma: Involvement of FOXE1, TSHR, and a Novel lincRNA Gene, PTCSC2

Author(s) -

Huiling He,

Wei Li,

Sandya Liyanarachchi,

Jarosław Jendrzejewski,

Mukund Srinivas,

Ramana V. Davuluri,

Rebecca Nagy,

Albert de la Chapelle

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-2147

Subject(s) - thyroid carcinoma , genetic predisposition , medicine , gene , thyroid , biology , cancer research , oncology , genetics

By genome-wide association studies, the risk allele [A] of SNP rs965513 predisposes strongly to papillary thyroid carcinoma (PTC). It is located in a gene-poor region of 9q22, some 60 kb from the FOXE1 gene. The underlying mechanisms remain to be discovered.

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