Human Uterine Leiomyoma Stem/Progenitor Cells Expressing CD34 and CD49b Initiate Tumors In Vivo | Zendy

Ping Yin | Zendy; Masanori Ono | Zendy; Molly B. Moravek | Zendy; John S. Coon | Zendy; Antònia Navarro | Zendy; Diana Monsivais | Zendy; Matthew T. Dyson | Zendy; Stacy A. Druschitz | Zendy; Saurabh Malpani | Zendy; Vanida A. Serna | Zendy; Wenan Qiang | Zendy; Debabrata Chakravarti | Zendy; Julie Kim | Zendy; Serdar E. Bulun | Zendy

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Human Uterine Leiomyoma Stem/Progenitor Cells Expressing CD34 and CD49b Initiate Tumors In Vivo

Author(s) -

Ping Yin,

Masanori Ono,

Molly B. Moravek,

John S. Coon,

Antònia Navarro,

Diana Monsivais,

Matthew T. Dyson,

Stacy A. Druschitz,

Saurabh Malpani,

Vanida A. Serna,

Wenan Qiang,

Debabrata Chakravarti,

Julie Kim,

Serdar E. Bulun

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-2134

Subject(s) - cd34 , progenitor cell , stem cell , leiomyoma , in vivo , biology , progenitor , cancer research , pathology , medicine , microbiology and biotechnology

Uterine leiomyoma is the most common benign tumor in reproductive-age women. Using a dye-exclusion technique, we previously identified a side population of leiomyoma cells exhibiting stem cell characteristics. However, unless mixed with mature myometrial cells, these leiomyoma side population cells did not survive or grow well in vitro or in vivo.

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