TGF-β1 Downregulates StAR Expression and Decreases Progesterone Production Through Smad3 and ERK1/2 Signaling Pathways in Human Granulosa Cells | Zendy

Lanlan Fang | Zendy; HsunMing Chang | Zendy; JungChien Cheng | Zendy; Peter C. K. Leung | Zendy; Yingpu Sun | Zendy

Open Access

TGF-β1 Downregulates StAR Expression and Decreases Progesterone Production Through Smad3 and ERK1/2 Signaling Pathways in Human Granulosa Cells

Author(s) -

Lanlan Fang,

HsunMing Chang,

JungChien Cheng,

Peter C. K. Leung,

Yingpu Sun

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-1930

Subject(s) - steroidogenic acute regulatory protein , progesterone receptor , granulosa cell , downregulation and upregulation , endocrinology , signal transduction , medicine , transforming growth factor , biology , follicular phase , receptor , messenger rna , chemistry , microbiology and biotechnology , estrogen receptor , gene , biochemistry , cancer , breast cancer

Regulation of progesterone production in granulosa cells is important for normal reproductive functions. Steroidogenic acute regulatory protein (StAR) is recognized as the key regulatory protein involved in the rate-limiting step of steroidogenesis. TGF-β1 protein is detected in human follicular fluid, and TGF-β1 and its receptors are expressed in human granulosa cells. However, the functional role of TGF-β1 in the regulation of StAR expression and progesterone production in human granulosa cells remains unknown.

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