Gonadotropin-Releasing Hormone Regulates Human Trophoblastic Cell Invasion via TWIST-Induced N-cadherin Expression | Zendy

Bo Peng | Zendy; Hua Zhu | Zendy; Peter C. K. Leung | Zendy

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Gonadotropin-Releasing Hormone Regulates Human Trophoblastic Cell Invasion via TWIST-Induced N-cadherin Expression

Author(s) -

Bo Peng,

Hua Zhu,

Peter C. K. Leung

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-1897

Subject(s) - gnrhr , cadherin , biology , trophoblast , gene knockdown , endocrinology , medicine , twist transcription factor , cell culture , receptor , microbiology and biotechnology , cancer research , gonadotropin releasing hormone , cell , downregulation and upregulation , placenta , epithelial–mesenchymal transition , hormone , fetus , luteinizing hormone , gene , pregnancy , biochemistry , genetics

GnRH and its receptor, GnRHR, were shown to promote trophoblastic cell invasion. Detection of elevated early development-related transcription factor TWIST and adhesion molecule N-cadherin in the invasive trophoblastic cells could suggest that GnRH promotes trophoblastic cell invasion through TWIST-regulated N-cadherin pathway.

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