The Sonic Hedgehog Signaling Pathway Maintains the Cancer Stem Cell Self-Renewal of Anaplastic Thyroid Cancer by Inducing Snail Expression | Zendy

Katherine Heiden | Zendy; Ashley J. Williamson | Zendy; Michelle E. Doscas | Zendy; Jin Ye | Zendy; Yimin Wang | Zendy; Dingxie Liu | Zendy; Mingzhao Xing | Zendy; Richard A. Prinz | Zendy; Xiulong Xu | Zendy

Open Access

The Sonic Hedgehog Signaling Pathway Maintains the Cancer Stem Cell Self-Renewal of Anaplastic Thyroid Cancer by Inducing Snail Expression

Author(s) -

Katherine Heiden,

Ashley J. Williamson,

Michelle E. Doscas,

Jin Ye,

Yimin Wang,

Dingxie Liu,

Mingzhao Xing,

Richard A. Prinz,

Xiulong Xu

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-1844

Subject(s) - gli1 , cyclopamine , anaplastic thyroid cancer , thyroid cancer , cancer research , cancer stem cell , hedgehog signaling pathway , thyroid , biology , stem cell , signal transduction , endocrinology , microbiology and biotechnology

Cancer stem cells (CSCs) have been recently identified in thyroid neoplasm. Anaplastic thyroid cancer (ATC) contains a higher percentage of CSCs than well-differentiated thyroid cancer. The signaling pathways and the transcription factors that regulate thyroid CSC self-renewal remain poorly understood.

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