Genetic Predictors of Long-Term Response to Growth Hormone (GH) Therapy in Children With GH Deficiency and Turner Syndrome: The Influence of a SOCS2 Polymorphism | Zendy

Adriana F. Braz | Zendy; Everlayny F. Costalonga | Zendy; Ericka Barbosa Trarbach | Zendy; Renata C. Scalco | Zendy; Alexsandra C. Malaquias | Zendy; Gil GuerraJúnior | Zendy; Sonir Roberto Rauber Antonini | Zendy; Berenice B. Mendonça | Zendy; Ivo J.P. Arnhold | Zendy; Alexander A.L. Jorge | Zendy

Open Access

Genetic Predictors of Long-Term Response to Growth Hormone (GH) Therapy in Children With GH Deficiency and Turner Syndrome: The Influence of a SOCS2 Polymorphism

Author(s) -

Adriana F. Braz,

Everlayny F. Costalonga,

Ericka Barbosa Trarbach,

Renata C. Scalco,

Alexsandra C. Malaquias,

Gil GuerraJúnior,

Sonir Roberto Rauber Antonini,

Berenice B. Mendonça,

Ivo J.P. Arnhold,

Alexander A.L. Jorge

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-1744

Subject(s) - igfbp3 , growth hormone receptor , medicine , endocrinology , allele , socs2 , genotype , biology , single nucleotide polymorphism , exon , turner syndrome , genetics , receptor , gene , growth hormone , hormone , growth factor , cancer , suppressor

There is great interindividual variability in the response to GH therapy. Ascertaining genetic factors can improve the accuracy of growth response predictions. Suppressor of cytokine signaling (SOCS)-2 is an intracellular negative regulator of GH receptor (GHR) signaling.

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