Dysregulated Sphingolipid Metabolism in Endometriosis | Zendy

Yie Hou Lee | Zendy; Chin Wen Tan | Zendy; Abhishek Venkatratnam | Zendy; Chuen Seng Tan | Zendy; Cui Liang | Zendy; Seong Feei Loh | Zendy; Linda G. Griffith | Zendy; Steven R. Tannenbaum | Zendy; Jerry Kok Yen Chan | Zendy

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Dysregulated Sphingolipid Metabolism in Endometriosis

Author(s) -

Yie Hou Lee,

Chin Wen Tan,

Abhishek Venkatratnam,

Chuen Seng Tan,

Cui Liang,

Seong Feei Loh,

Linda G. Griffith,

Steven R. Tannenbaum,

Jerry Kok Yen Chan

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-1340

Subject(s) - sphingolipid , sphingomyelin , endometriosis , ceramide , endometrium , endocrinology , biology , medicine , peritoneal fluid , lipidomics , cancer research , apoptosis , microbiology and biotechnology , biochemistry , cholesterol

In endometriosis, the establishment and subsistence of ectopic lesions outside the endometrium suggest an altered cellular state for pathological hyperplasia. Sphingolipids are bioactive compounds, and their biosynthesis and metabolism modulate a range of cellular processes including proliferation, migration and apoptosis. We demonstrate that aberrations in sphingolipid metabolism occur in women with endometriosis.

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