The Level of Circulating Octanoate Does Not Predict GhrelinO-Acyl Transferase (GOAT)-Mediated Acylation of Ghrelin During Fasting | Zendy

Ralf Nass | Zendy; Alexander Nikolayev | Zendy; Jianhua Liu | Zendy; Suzan S. Pezzoli | Zendy; Leon S. Farhy | Zendy; James T. Patrie | Zendy; Bruce D. Gaylinn | Zendy; Mark L. Heiman | Zendy; Michael O. Thorner | Zendy

Open Access

The Level of Circulating Octanoate Does Not Predict GhrelinO-Acyl Transferase (GOAT)-Mediated Acylation of Ghrelin During Fasting

Author(s) -

Ralf Nass,

Alexander Nikolayev,

Jianhua Liu,

Suzan S. Pezzoli,

Leon S. Farhy,

James T. Patrie,

Bruce D. Gaylinn,

Mark L. Heiman,

Michael O. Thorner

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2014-1318

Subject(s) - ghrelin , acylation , medicine , endocrinology , chemistry , biochemistry , hormone , biology , catalysis

Acyl-ghrelin is a 28-amino acid peptide released from the stomach. Ghrelin O-acyl transferase (GOAT) attaches an 8-carbon medium-chain fatty acid (MCFA) (octanoate) to serine 3 of ghrelin. This acylation is necessary for the activity of ghrelin. Animal data suggest that MCFAs provide substrate for GOAT and an increase in nutritional octanoate increases acyl-ghrelin.

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