Open AccessReduced GLP-1R Expression in Gastric Glands of Patients With Type 2 Diabetes Mellitus
Author(s) -
Efrat Broide,
Olga Bloch,
Gilad Ben-Yehudah,
Dror Cantrell,
Haim Shirin,
Micha J. Rapoport
Publication year - 2014
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2014-1114
Subject(s) - medicine , incretin , endocrinology , immunostaining , immunohistochemistry , stomach , type 2 diabetes mellitus , antrum , gastric mucosa , diabetes mellitus , type 2 diabetes
The incretin effect is reduced in type 2 diabetes mellitus (T2DM) patients. Whether the impaired function of the enteropancreatic axis in these patients is due to defective GLP-1 receptor (GLP-1R) expression in extrapancreatic target organs is not known.
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