Open AccessThe Expression of the miR-25/93/106b Family of Micro-RNAs in the Adipose Tissue of Women With Polycystic Ovary Syndrome
Author(s) -
Hsiao-Li Wu,
Saleh Heneidi,
T.Y. Chuang,
Michael P. Diamond,
Lawrence C. Layman,
Ricardo Azziz,
Yen-Hao Chen
Publication year - 2014
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-4435
Subject(s) - polycystic ovary , insulin resistance , endocrinology , medicine , adipose tissue , gene expression , biology , insulin , ovary , glucose transporter , microrna , carbohydrate metabolism , gene isoform , gene , genetics
In adipose tissue (AT) micro-RNA-93 (miR-93) is significantly overexpressed in polycystic ovary syndrome (PCOS) women and non-PCOS women with insulin resistance (IR). Overexpressed miR-93 directly inhibits glucose transporter isoform 4, impairing both glucose metabolism and insulin sensitivity. The mechanisms behind increased miR-93 expression are unclear.
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