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The homogeneous distribution of BRAF V600E in papillary thyroid carcinoma (PTC) has been called into question by recent reports. These studies claim that BRAF V600E is heterogeneous and is limited to tumor cell subsets in the majority of PTCs.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

High-Sensitivity<i>BRAF</i>Mutation Analysis:<i>BRAF</i>V600E Is Acquired Early During Tumor Development but Is Heterogeneously Distributed in a Subset of Papillary Thyroid Carcinomas

High-SensitivityBRAFMutation Analysis:BRAFV600E Is Acquired Early During Tumor Development but Is Heterogeneously Distributed in a Subset of Papillary Thyroid Carcinomas