Open AccessHigh-SensitivityBRAFMutation Analysis:BRAFV600E Is Acquired Early During Tumor Development but Is Heterogeneously Distributed in a Subset of Papillary Thyroid Carcinomas
Author(s) -
Dario de Biase,
V. Cesari,
Michela Visani,
Gian Piero Casadei,
Nadia Cremonini,
Greta Gandolfi,
Valentina Sancisi,
Moira Ragazzi,
Annalisa Pession,
Alessia Ciarrocchi,
Giovanni Tallini
Publication year - 2014
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-4389
Subject(s) - v600e , cancer research , thyroid carcinoma , mutation , biology , exon , point mutation , nucleic acid , thyroid , pathology , medicine , gene , genetics
The homogeneous distribution of BRAF V600E in papillary thyroid carcinoma (PTC) has been called into question by recent reports. These studies claim that BRAF V600E is heterogeneous and is limited to tumor cell subsets in the majority of PTCs.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom