Open AccessGlycation of the Complement Regulatory Protein CD59 Is a Novel Biomarker for Glucose Handling in Humans
Author(s) -
Pamela Ghosh,
Anand Vaidya,
Rupam Sahoo,
Allison B. Goldfine,
Neil Herring,
Lynn Bry,
Michael Chorev,
José A. Halperin
Publication year - 2014
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-4232
Subject(s) - medicine , glycation , diabetes mellitus , endocrinology , glycemic , insulin , glycated hemoglobin , biomarker , type 2 diabetes , biology , biochemistry
Human CD59, an inhibitor of the membrane attack complex of complement, is inactivated by glycation. Glycation inactivation of CD59 enhances complement-mediated injury in target organs of diabetes complications.
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