Continuous 24-Hour Leptin, Proopiomelanocortin, and Amino Acid Measurements in Human Cerebrospinal Fluid: Correlations With Plasma Leptin, Soluble Leptin Receptor, and Amino Acid Levels | Zendy

Sharon L. Wardlaw | Zendy; Charles Burant | Zendy; Samuel Klein | Zendy; Kana Meece | Zendy; Anne White | Zendy; Tom Kasten | Zendy; Brendan P. Lucey | Zendy; Randall J. Bateman | Zendy

Open Access

Continuous 24-Hour Leptin, Proopiomelanocortin, and Amino Acid Measurements in Human Cerebrospinal Fluid: Correlations With Plasma Leptin, Soluble Leptin Receptor, and Amino Acid Levels

Author(s) -

Sharon L. Wardlaw,

Charles Burant,

Samuel Klein,

Kana Meece,

Anne White,

Tom Kasten,

Brendan P. Lucey,

Randall J. Bateman

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2013-4087

Subject(s) - leptin , proopiomelanocortin , medicine , endocrinology , cerebrospinal fluid , chemistry , leptin receptor , hypothalamus , circadian rhythm , biology , obesity

In order to characterize diurnal changes in central leptin and its target neuropeptide, proopiomelanocortin (POMC), we measured leptin and POMC in cerebrospinal fluid (CSF) as related to changes in plasma leptin and soluble leptin receptor (sOB-R) levels. CSF and plasma levels of 20 amino acids (AA) were also measured because AA can affect brain POMC.

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