Progesterone Pharmacokinetics and Pharmacodynamics With 3 Dosages and 2 Regimens of an Effervescent Micronized Progesterone Vaginal Insert | Zendy

Richard J. Paulson | Zendy; Michael G. Collins | Zendy; Vladimir I. Yankov | Zendy

Open Access

Progesterone Pharmacokinetics and Pharmacodynamics With 3 Dosages and 2 Regimens of an Effervescent Micronized Progesterone Vaginal Insert

Author(s) -

Richard J. Paulson,

Michael G. Collins,

Vladimir I. Yankov

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2013-3937

Subject(s) - cmax , pharmacokinetics , pharmacodynamics , medicine , area under the curve , dose , endometrial biopsy , endocrinology , progesterone receptor , endometrium , estrogen receptor , cancer , breast cancer

Progesterone vaginal insert (PVI), an effervescent delivery system, dissolves rapidly, is absorbed through the vaginal epithelium, and achieves higher endometrial tissue concentrations than those achieved with progesterone in oil (PIO) given im.

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