Open AccessDecreased Cholesterol Efflux Capacity and Atherogenic Lipid Profile in Young Women With PCOS
Author(s) -
Andrea H. Roe,
Jennifer Hillman,
Samantha Butts,
M P Smith,
Daniel J. Rader,
Martin P. Playford,
Nehal N. Mehta,
Anuja Dokras
Publication year - 2014
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-3918
Subject(s) - medicine , endocrinology , cholesterol , body mass index , apolipoprotein b , dyslipidemia , polycystic ovary , lipoprotein , lipid profile , apolipoprotein a1 , blood lipids , biology , insulin resistance , obesity
Women with polycystic ovary syndrome (PCOS) have a high prevalence of cardiovascular disease (CVD) risk factors including dyslipidemia. Lipoproteins are heterogeneous, and measurement of serum lipids provides only the size of the pool and does not predict their function or composition. Recently, high-density lipoprotein cholesterol (HDL-C) function, as determined by cholesterol efflux capacity from macrophages, has been shown to be an independent predictor of subclinical CVD.
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