Stemness in Human Thyroid Cancers and Derived Cell Lines: The Role of Asymmetrically Dividing Cancer Stem Cells Resistant to Chemotherapy | Zendy

Risheng Ma | Zendy; Noga Minsky | Zendy; Syed A. Morshed | Zendy; Terry F. Davies | Zendy

Open Access

Stemness in Human Thyroid Cancers and Derived Cell Lines: The Role of Asymmetrically Dividing Cancer Stem Cells Resistant to Chemotherapy

Author(s) -

Risheng Ma,

Noga Minsky,

Syed A. Morshed,

Terry F. Davies

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2013-3545

Subject(s) - cancer stem cell , sox2 , homeobox protein nanog , cancer research , biology , stem cell , thyroid cancer , progenitor cell , population , embryonic stem cell , cancer , induced pluripotent stem cell , microbiology and biotechnology , medicine , genetics , environmental health , gene

Cancer stem cells (CSCs) have the ability to self-renew through symmetric and asymmetric cell division. CSCs may arise from mutations within an embryonic stem cell/progenitor cell population or via epithelial-mesenchymal transition (EMT), and recent advances in the study of thyroid stem cells have led to a growing recognition of the likely central importance of CSCs in thyroid tumorigenesis.

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