Open AccessAge- and Sex-Specific Reference Intervals Across Life Span for Insulin-Like Growth Factor Binding Protein 3 (IGFBP-3) and the IGF-I to IGFBP-3 Ratio Measured by New Automated Chemiluminescence Assays
Author(s) -
Nele Friedrich,
Ole D. Wolthers,
Ayman M. Arafat,
Rebecca T. Emeny,
Joachim Spranger,
Josefine Roswall,
Jürgen Kratzsch,
Hans J. Grabe,
Christoph Hübener,
Andreas Pfeiffer,
Angela Döring,
Maximilian Bielohuby,
Jovanna Dahlgren,
Jan Frystyk,
Henri Wallaschofski,
Martin Bidlingmaier
Publication year - 2014
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-3060
Subject(s) - insulin like growth factor , medicine , insulin like growth factor binding protein , growth factor , chemiluminescence , endocrinology , biology , chemistry , receptor , organic chemistry
Measurement of IGF-binding protein-3 (IGFBP-3) can aid the diagnosis of GH-related diseases. Furthermore, epidemiological studies suggest that IGFBP-3 and the molar IGF-I to IGFBP-3 ratio are associated with clinical end points like cancer or cardiovascular disease. However, their clinical use is limited by the lack of validated reference intervals.
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