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Medroxyprogesterone Acetate Enhances Monocyte-Endothelial Interaction Under Flow Conditions by Stimulating the Expression of Cell Adhesion Molecules
Author(s) -
Fumitake Ito,
Hiroshi Tatsumi,
Taisuke Mori,
Izumi Suganuma,
Yukiko Tanaka,
Aya Sasaki,
Seiki Matsuo,
Koichi Iwasa,
Jo Kitawaki
Publication year - 2014
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-2925
Subject(s) - cell adhesion molecule , monocyte , medroxyprogesterone acetate , adhesion , microbiology and biotechnology , cell adhesion , chemistry , flow (mathematics) , biology , immunology , biochemistry , mathematics , hormone , geometry , organic chemistry
Monocyte adhesion to endothelial cells is an important initial event in atherosclerosis and is partially mediated by adhesion molecule expression on the cell surface. Although estrogens inhibit atherosclerosis development, effects of coadministered progestogen remain controversial.

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