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Tumor-induced osteomalacia (TIO) is an acquired hypophosphatemic metabolic bone disorder that can be cured by removing or ablating the offending tumor. However, when the tumor cannot be localized, lifelong therapy with oral phosphate and calcitriol or cinacalcet with close monitoring is required.

Deliberate Total Parathyroidectomy: A Potentially Novel Therapy for Tumor-Induced Hypophosphatemic Osteomalacia