Open AccessProgression of Vertebral Fractures Despite Long-Term Biochemical Control of Acromegaly: A Prospective Follow-up Study
Author(s) -
Kim M. J. A. Claessen,
Herman M. Kroon,
Alberto M. Pereira,
Natasha M. AppelmanDijkstra,
Marco J. T. Verstegen,
M. Kloppenburg,
Neveen A. T. Hamdy,
Nienke R. Biermasz
Publication year - 2013
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-2695
Subject(s) - acromegaly , medicine , bone mineral , prospective cohort study , surgery , osteoporosis , hormone , growth hormone
In active acromegaly, pathologically elevated GH and IGF-1 levels are associated with increased bone turnover and a high bone mass, the latter being sustained after normalization of GH values. In a cross-sectional study design, we have previously reported a high prevalence of vertebral fractures (VFs) of about 60% in patients with controlled acromegaly, despite normal mean bone mineral density (BMD) values. Whether these fractures occur during the active acromegaly phase or after remission is achieved is not known.
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