Open AccessSkewed X Chromosome Inactivation and Female Preponderance in Autoimmune Thyroid Disease: An Association Study and Meta-Analysis
Author(s) -
Matthew J. Simmonds,
Fotini K. Kavvoura,
Stephan Brand,
Paul Newby,
L. Elizabeth Jackson,
Chantal E. Hargreaves,
Jayne A. Franklyn,
Stephen Gough
Publication year - 2013
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-2667
Subject(s) - odds ratio , medicine , graves' disease , confidence interval , meta analysis , case control study , cohort study , cohort , subgroup analysis , thyroiditis , x inactivation , thyroid , x chromosome , endocrinology , genetics , biology , gene
A number of small data sets have suggested a potential role for skewed X chromosome activation (XCI), away from the expected 50:50 parent of origin ratio, as an explanation for the strong female preponderance seen in the common autoimmune thyroid diseases (AITD), Graves' disease (GD), and Hashimoto's thyroiditis (HT).
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