Open AccessAnnexin V Expression and Anti-Annexin V Antibodies in Type 1 Diabetes
Author(s) -
Filiz BakarAtes,
Uğur Ünlütürk,
Nilgün Başkal,
Serpil Nebioğlu
Publication year - 2014
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-2592
Subject(s) - medicine , type 1 diabetes , endocrinology , autoimmunity , diabetes mellitus , antibody , autoimmune disease , annexin , inflammation , immunology , platelet , type 2 diabetes , annexin a2 , disease , autoantibody , pathogenesis , flow cytometry
Annexin V (AnxV) has potent anticoagulant properties and regulatory functions for apoptosis and inflammation. Antibodies against annexin V (anti-AnxVs) may inhibit AnxV functions, leading to thrombosis during autoimmune diseases. Type 1 diabetes is an autoimmune disease and related with an ongoing autoimmune inflammation and thrombotic complications. There is no study evaluating anti-AnxVs/AnxV in a disease setting.
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