Open AccessDetection of Thyroid Cancer Stem Cells in Papillary Thyroid Carcinoma
Author(s) -
SoonHyun Ahn,
Ying C. Henderson,
Michelle D. Williams,
Stephen Y. Lai,
Gary L. Clayman
Publication year - 2013
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-2558
Subject(s) - thyroid cancer , thyroid carcinoma , medicine , papillary carcinoma , thyroid , cancer research , oncology , pathology
Special populations of cells that can efficiently initiate tumor growth have been characterized, and this feature supports the cancer stem cell theory. These cancer stem cell populations have been identified with CD44 and POU5F1. Most cancer stem cells express high levels of CD44 and low levels of CD24. In thyroid lesions, cancer stem cells have been detected in anaplastic carcinoma. However, little is known about the presence of cancer stem cells in papillary thyroid carcinoma (PTC), especially in recurrent PTC.
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