Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1α Enhances Local Estrogen Biosynthesis by Stimulating Aromatase Activity in Endometriosis | Zendy

Izumi Suganuma | Zendy; Taisuke Mori | Zendy; Fumitake Ito | Zendy; Yukiko Tanaka | Zendy; Aya Sasaki | Zendy; Seiki Matsuo | Zendy; Izumi Kusuki | Zendy; Jo Kitawaki | Zendy

Open Access

Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1α Enhances Local Estrogen Biosynthesis by Stimulating Aromatase Activity in Endometriosis

Author(s) -

Izumi Suganuma,

Taisuke Mori,

Fumitake Ito,

Yukiko Tanaka,

Aya Sasaki,

Seiki Matsuo,

Izumi Kusuki,

Jo Kitawaki

Publication year - 2014

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2013-2525

Subject(s) - aromatase , coactivator , endocrinology , medicine , estrogen , biology , transcription factor , gene , biochemistry , cancer , breast cancer

Endometriosis is an estrogen-dependent disease, and estrogen is overproduced by abnormally elevated aromatase in endometriotic tissues. Peroxisome proliferator-activated receptor gamma, coactivator 1α (PGC-1α) is a transcriptional coactivator-modulating steroid hormone.

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