Open AccessEffects of ACE I/D Polymorphism and Aerobic Training on the Immune–Endocrine Network and Cardiovascular Parameters of Postmenopausal Women
Author(s) -
Pascal Izzicupo,
Barbara Ghinassi,
Maria Angela D’Amico,
Andrea Di Blasio,
Marco Gesi,
Giorgio Napolitano,
Sabina Gallina,
Angela Di Baldassarre
Publication year - 2013
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-2305
Subject(s) - medicine , endocrinology , adiponectin , angiotensin converting enzyme , dehydroepiandrosterone , dehydroepiandrosterone sulfate , blood pressure , endocrine system , genotype , hormone , insulin resistance , insulin , biology , androgen , gene , biochemistry
Estrogen deficiency, systemic low-grade inflammation, and reduction of adrenal gland function have central roles in noncommunicable chronic disease (NCD) development. With angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism, the deletion variant (DD) is related to higher levels of circulating angiotensin II than I allele carriers (II/ID), which might interact with all of these molecular pathways to increase NCDs risk. On the other hand, physical exercise counteracts the occurrence of NCDs, potentially acting on the same pathways.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom