Falsely Undetectable TSH in a Cohort of South Asian Euthyroid Patients | Zendy

Julia C. Drees | Zendy; Judith Stone | Zendy; C. Randy Reamer | Zendy; Victoria E. Arboleda | Zendy; Karl Huang | Zendy; Jane Hrynkow | Zendy; Di. Greene | Zendy; Matthew S. Petrie | Zendy; Carolyn Hoke | Zendy; Thomas Lorey | Zendy; Richard Dlott | Zendy

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Falsely Undetectable TSH in a Cohort of South Asian Euthyroid Patients

Author(s) -

Julia C. Drees,

Judith Stone,

C. Randy Reamer,

Victoria E. Arboleda,

Karl Huang,

Jane Hrynkow,

Di. Greene,

Matthew S. Petrie,

Carolyn Hoke,

Thomas Lorey,

Richard Dlott

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2013-2092

Subject(s) - euthyroid , cohort , medicine , endocrinology , thyroid

An index case of a clinically euthyroid woman of South Asian descent was identified with discordant TSH results: undetectable TSH on our routine assay and normal TSH on an alternate assay. Low TSH concentrations due to functionally compromising TSH mutations have been reported. Here we describe a new phenomenon of functional TSH that is undetectable by 4 widely used US Food and Drug Administration (FDA)-approved TSH immunoassays marketed by a single vendor.

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