Open AccessNeurodevelopmental and Body Composition Outcomes in Children With Congenital Hypothyroidism Treated With High-Dose Initial Replacement and Close Monitoring
Author(s) -
Benjamin B. Albert,
Natasha Heather,
José G. B. Derraik,
Wayne S. Cutfield,
Trecia A. Wouldes,
Sheryl Tregurtha,
Sarah Mathai,
Dianne Webster,
Craig Jefferies,
Alistair J. Gunn,
Paul L. Hofman
Publication year - 2013
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2013-1903
Subject(s) - levothyroxine , neurocognitive , medicine , congenital hypothyroidism , pediatrics , intelligence quotient , anthropometry , thyroid function , wechsler adult intelligence scale , cognition , thyroid , psychiatry
Despite newborn screening and early levothyroxine replacement, there are continued reports of mild neurocognitive impairment in children with congenital hypothyroidism (CHT). In Auckland, New Zealand, cases are identified by a neonatal screening program with rapid institution of high-dose levothyroxine replacement (10-15 μg/kg·d), producing prompt normalization of thyroid function. Subsequently, frequent monitoring and dose alterations are performed for 2 years. We aimed to assess whether the Auckland treatment strategy prevents impairment of intellectual and motor development.
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