Metformin Inhibits Follicle-Stimulating Hormone (FSH) Action in Human Granulosa Cells: Relevance to Polycystic Ovary Syndrome | Zendy

Suman Rice | Zendy; Androulla Elia | Zendy; Zara Jawad | Zendy; Laura Pellatt | Zendy; Helen Mason | Zendy

Open Access

Metformin Inhibits Follicle-Stimulating Hormone (FSH) Action in Human Granulosa Cells: Relevance to Polycystic Ovary Syndrome

Author(s) -

Suman Rice,

Androulla Elia,

Zara Jawad,

Laura Pellatt,

Helen Mason

Publication year - 2013

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2013-1865

Subject(s) - polycystic ovary , metformin , medicine , endocrinology , follicle stimulating hormone , ovary , follicle , hormone , biology , luteinizing hormone , insulin , insulin resistance

Women with anovulatory polycystic ovary syndrome (PCOS) are generally insulin-resistant and as a consequence are often treated with the biguanide metformin. Results with metformin have, however, been variable with some studies demonstrating induction of regular cycles and an increase in ovulation, whereas others do not. Hence more understanding is needed regarding the mechanism of metformin's actions in ovarian granulosa cells especially in light of previous demonstrations of direct actions.

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